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Designed Journal Covers

Journal Papers

Note: #Co-first authors; *Corresponding author(s); Underscore: lab member/alumnus

    In Submission

  1. Working on it!

    Selected Publications

  1. StratoLAMP: Label-free, multiplex digital loop-mediated isothermal amplification based on visual stratification of precipitate
    Meichi Jin,# Jingyi Ding,# Yu Zhou, Jiazhao Chen, Yi Wang, and Zida Li*
    Proceedings of the National Academy of Sciences , 121(2), e2314030121, 2024
    DOI | PDF
  2. deep-dLAMP: deep learning-enabled polydisperse emulsion-based digital loop-mediated isothermal amplification
    Linzhe Chen,# Jingyi Ding,# Hao Yuan, Chi Chen,* and Zida Li*
    Advanced Science , 9(9), 2105450, 2022
    DOI | PDF
  3. Combinatorial perturbation sequencing on single cells using microwell-based droplet random pairing
    Run Xie,# Yang Liu,# Shiyu Wang, Xuyang Shi, Zhantao Zhao, Longqi Liu, Ya Liu,* and Zida Li*
    Biosensors and Bioelectronics , 220, 114913, 2023
    DOI | PDF
  4. CoID-LAMP: Color-encoded, intelligent digital LAMP for multiplexed nucleic acid quantification
    Kai Wu,# Qi Fang,# Zhantao Zhao, and Zida Li*
    Analytical Chemistry , 95(11), 5069–5078, 2023
    DOI | PDF
  5. Point-of-care blood coagulation assay based on dynamic monitoring of blood viscosity using droplet microfluidics
    Linzhe Chen, Donghao Li, Xinyu Liu, Yihan Xie, Jieying Shan, Haofan Huang, Xiaxia Yu, Yudan Chen, Weidong Zheng, and Zida Li*
    ACS Sensors , 7(8), 2170–2177, 2022
    DOI | PDF
  6. Controlled modeling of human epiblast and amnion development using stem cells
    Yi Zheng, Xufeng Xue, Yue Shao, Sicong Wang, Sajedeh Nasr Esfahani, Zida Li, Jonathon M. Muncie, Johnathon N. Lakins, Valerie M. Weaver, Deborah L. Gumucio, and Jianping Fu*
    Nature , 573(7774), 421-425, 2019
    DOI | PDF | Media Coverage
  7. Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a neurogenic niche
    Yuanyuan Zheng,# Xufeng Xue,# Agnes M. Resto Irizarry, Zida Li, Yue Shao, Yi Zheng, Gang Zhao,* and Jianping Fu*
    Science Advances , 5(12), eaax5993, 2019
    DOI | PDF

    2024

  1. Embracing Poisson encapsulation statistics for improved droplet digital immunoassay
    Yujuan Chai, Xiaoxiang Hu, Qi Fang, Yuanyuan Guo, Binmao Zhang, Hangjia Tu, and Zida Li*
    Analytical Chemistry , in press
    DOI | PDF
  2. Image-activated pico-injection for single cell analysis
    Zhantao Zhao, Heng Zhai, Peng Zuo, Tao Wang, Run Xie, Mu Tian, Ruyuan Song, Xiaonan Xu, and Zida Li*
    Talanta , 272, 125765, 2024
    DOI | PDF
  3. StratoLAMP: Label-free, multiplex digital loop-mediated isothermal amplification based on visual stratification of precipitate
    Meichi Jin,# Jingyi Ding,# Yu Zhou, Jiazhao Chen, Yi Wang, and Zida Li*
    Proceedings of the National Academy of Sciences , 121(2), e2314030121, 2024
    DOI | PDF

    4. 2023

  4. High resolution, multiplex antibody patterning using micropillar-focused droplet printing and microcontact printing
    Meichi Jin, Kai Wu, Mengzhen Wang, Yang Zhang, Chengbin Yang, and Zida Li*
    Advanced Biology , 7(8), 2300111, 2023
    DOI | PDF
  5. CoID-LAMP: Color-encoded, intelligent digital LAMP for multiplexed nucleic acid quantification
    Kai Wu,# Qi Fang,# Zhantao Zhao, and Zida Li*
    Analytical Chemistry , 95(11), 5069–5078, 2023
    DOI | PDF
  6. Combinatorial perturbation sequencing on single cells using microwell-based droplet random pairing
    Run Xie,# Yang Liu,# Shiyu Wang, Xuyang Shi, Zhantao Zhao, Longqi Liu, Ya Liu,* and Zida Li*
    Biosensors and Bioelectronics , 220, 114913, 2023
    DOI | PDF
  7. Bone-on-a-chip platforms and integrated biosensors: towards advanced in vitro bone models with real-time biosensing
    Yang Zhang, Taozhao Yu, Jingyi Ding, and Zida Li*
    Biosensors and Bioelectronics , 219, 114798, 2023
    DOI | PDF

    8. 2022

  8. Point-of-care blood coagulation assay based on dynamic monitoring of blood viscosity using droplet microfluidics
    Linzhe Chen, Donghao Li, Xinyu Liu, Yihan Xie, Jieying Shan, Haofan Huang, Xiaxia Yu, Yudan Chen, Weidong Zheng, and Zida Li*
    ACS Sensors , 7(8), 2170–2177, 2022
    DOI | PDF
  9. Generation and Screening of Antigen-Specific Nanobodies from Mammalian Cells Expressing the BCR Repertoire Library Using Droplet-Based Microfluidics
    Menghua Lyu,# Xuyang Shi,# Xiaopan Liu,# Yang Liu, Xijun Zhu, Lijuan Liao, Hongyan Zhao, Na Sun, Shiyu Wang, Linzhe Chen, Linyuan Fan, Qumiao Xu, Qianqian Zhu, Kai Gao, Huaying Chen, Yonggang Zhu, Zida Li, Weijin Guo, Yue Zheng, Yue Zheng, Ying Gu, Longqi Liu,* Meiniang Wang,* and Ya Liu*
    Analytical Chemistry , 94(22), 7970–7980, 2022
    DOI | PDF
  10. Point-of-care blood coagulation assay enabled by printed circuit board-based digital microfluidics
    Donghao Li,# Xinyu Liu,# Yujuan Chai,# Jieying Shan, Yihan Xie, Yong Liang, Susu Huang, Weidong Zheng, and Zida Li*
    Lab on a Chip , 22(4), 709-716, 2022
    DOI | PDF
  11. deep-dLAMP: deep learning-enabled polydisperse emulsion-based digital loop-mediated isothermal amplification
    Linzhe Chen,# Jingyi Ding,# Hao Yuan, Chi Chen,* and Zida Li*
    Advanced Science , 9(9), 2105450, 2022
    DOI | PDF
  12. Single-cell sequencing to unveil the mystery of embryonic development
    Zida Li,#,* Feng Lin,# Chu-Han Zhong, Shue Wang, Xufeng Xue, and Yue Shao*
    Advanced Biology , 6(2), 2101151, 2022
    DOI | PDF
  13. High-throughput functional screening of antigen-specific T-cells based on droplet microfluidics on single-cell level
    Shiyu Wang,# Yang Liu,# Yijian Li, Menghua Lv, Kai Gao, Ying He, Wenbo Wei, Yonggang Zhu, Xuan Dong, Xun Xu, Zida Li,* Longqi Liu,* and Ya Liu*
    Analytical Chemistry , 94(2), 918–926, 2022
    DOI | PDF

    14. 2021

  14. Emerging biosensing technologies for improved diagnostics of COVID-19 and future pandemics
    Linzhe Chen, Guoliang Zhang, Longqi Liu*, and Zida Li*
    Talanta , 225, 121986, 2021
    DOI | PDF

    15. 2020

  15. Micro-engineered flexural post rings for effective blood sample fencing and high throughput measurement of clot retraction force
    Lanzhu Huang,# Xinyu Liu,# Yuanbin Ou, Haofan Huang, Xia Zhang, Yize Wang, Yong Liang, Xiaxia Yu, Weidong Zheng, Huisheng Zhang, and Zida Li*
    ACS Sensors , 5(12), 3949-3955, 2020
    DOI | PDF
  16. Recent advances in solar-driven evaporation system
    Zhourui Xu, Zida Li, Yihang Jiang, Gaixia Xu, Mingwei Zhu, Wing-Cheung Law, Ken-Tye Yong, Yanshuai Wang, Chengbin Yang, Biqin Dong, and Feng Xing*
    Journal of Materials Chemistry A , 8, 25571-25600, 2020
    DOI | PDF
  17. Stretchable supercapacitors as emergent energy storage units for health monitoring bioelectronics
    Xue Chen, Nicolo Simone Villa, Yanfeng Zhuang, Linzhe Chen, Tianfu Wang, Zida Li*, and Tiantian Kong*
    Advanced Energy Materials , 10(4), 1902769, 2020
    DOI | PDF

    18. 2019

  18. Dean flow assisted single cell and bead encapsulation for high performance single cell expression profiling
    Luoquan Li,# Ping Wu,# Zhaofeng Luo, Lei Wang, Weiping Ding, Tao Wu, Jinyu Chen, Jinlong He, Yi He, Heran Wang, Ying Chen, Guibo Li, Zida Li,* and Liqun He*
    ACS Sensors , 4(5), 1299-1305, 2019
    DOI | PDF
  19. Multiple splitting of droplets using multi-furcating microfluidic channels
    Zida Li*, Luoquan Li, Meixiang Liao, Liqun He, and Ping Wu*
    Biomicrofluidics , 13(2), 024112, 2019
    DOI | PDF

    20. Before SZU

  20. Controlled modeling of human epiblast and amnion development using stem cells
    Yi Zheng, Xufeng Xue, Yue Shao, Sicong Wang, Sajedeh Nasr Esfahani, Zida Li, Jonathon M. Muncie, Johnathon N. Lakins, Valerie M. Weaver, Deborah L. Gumucio, and Jianping Fu*
    Nature , 573(7774), 421-425, 2019
    DOI | PDF | Media Coverage
  21. Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a neurogenic niche
    Yuanyuan Zheng,# Xufeng Xue,# Agnes M. Resto Irizarry, Zida Li, Yue Shao, Yi Zheng, Gang Zhao,* and Jianping Fu*
    Science Advances , 5(12), eaax5993, 2019
    DOI | PDF
  22. Microengineered human amniotic ectoderm tissue array for high-content developmental phenotyping
    Sajedeh Nasr Esfahani, Yue Shao, Agnes M Resto Irizarry, Zida Li, Xufeng Xue, Deborah L Gumucio, and Jianping Fu*
    Biomaterials , 216, 119244, 2019
    DOI | PDF
  23. Biophysical phenotypes and determinants of anterior vs. posterior primitive streak cells derived from human pluripotent stem cells
    Feng Lin, Yue Shao, Xufeng Xue, Yi Zheng, Zida Li, Chunyang Xiong*, and Jianping Fu*
    Acta Biomaterialia , 86, 125-134, 2019
    DOI | PDF
  24. Carbon nanotube strain sensor based hemoretractometer for blood coagulation testing
    Zida Li, Yize Wang, Xufeng Xue, Brendan McCracken, Kevin Ward, and Jianping Fu*
    ACS Sensors , 3(3), 670-676, 2018
    DOI | PDF
  25. Capillary assisted deposition of carbon nanotube film for strain sensing
    Zida Li, Xufeng Xue, Feng Lin, Yize Wang, Kevin Ward, and Jianping Fu*
    Applied Physics Letters , 111(17), 173105, 2017
    DOI | PDF
  26. Tracking the tumor invasion front using long-term fluidic tumoroid culture
    Koh Meng Aw Yong, Zida Li, Sofia D. Merajver, and Jianping Fu*
    Scientific Reports , 7, 2017
    DOI | PDF
  27. Acoustic tweezing cytometry enhances osteogenesis of human mesenchymal stem cells through cytoskeletal contractility and YAP activation
    Xuefeng Xue, Xiaowei Hong, Zida Li, Cheri X. Deng, and Jianping Fu*
    Biomaterials , 134, 22-30, 2017
    DOI | PDF
  28. Controlled tubular unit formation from collagen film for modular tissue engineering
    Jianming Sang, Xiang Li, Yue Shao, Zida Li, and Jianping Fu*
    ACS Biomaterials Science & Engineering , 3 (11), 2860-2868, 2016
    DOI | PDF
  29. A miniaturized hemoretractometer for blood clot retraction testing
    Zida Li, Xiang Li, Brendan McCracken, Yue Shao, Kevin Ward, and Jianping Fu*
    Small , 12, 3926–3934, 2016
    DOI | PDF
  30. Musical interfaces: visualization and reconstruction of music with a microfluidic two-phase flow
    Sze Yi Mak, Zida Li, Arnaud Frere, Tat Chuen Chan, and Ho Cheung Shum*
    Scientific Reports , 4, 6675, 2014
    DOI | PDF
  31. Syringe-pump-induced fluctuation in all-aqueous microfluidic system implications for flow rate accuracy
    Zida Li, Sze Yi Mak, Alban Sauret, and Ho Cheung Shum*
    Lab on a Chip , 14(4), 744-749, 2014
    DOI | PDF
  32. Emerging microengineered tools for functional analysis and phenotyping of blood cells
    Xiang Li, Weiqiang Chen, Zida Li, Ling Li, Hongchen Gu, and Jianping Fu*
    Trends in Biotechnology , 32(11), 586-594, 2014
    DOI | PDF
  33. Dynamics for dense packing of colloids
    Liqun He*, Ping Wu, Zida Li, and Lili Feng
    Advanced Materials Research , 165, 248-254, 2012
    DOI | PDF

Book Chapters

  1. Nanotechnology and microfluidics for biosensing and biophysical property assessment: implications for next generation in vitro diagnostics
    Zida Li* and Anderson Ho Cheung Shum*
    Nanotechnology and Microfluidics, edited by Xingyu Jiang, Chunli Bai, and Minghua Liu , 83-107, John Wiley & Sons, 2019
    DOI | PDF

Patents

  1. A Droplet Digital Enzyme-Linked Immunosorbent Assay Method, Device, and Related Medium
    Zida Li, Qi Fang, Yujun Chai, Xiaoxiang Hu
    China Invention Patent Provisional Application , CN202410149722.7, 2024
  2. A nucleic acid quantification method based on non-uniform droplets and image analysis
    Zida Li, Jingyi Ding, Linzhe Chen, and Chi Chen
    China Invention Patent Provisional Application , CN114540469A, 2022
  3. A detection system and method for point-of-care blood clotting function assessment
    Zida Li, Donghao Li, Yujuan Chai, Xinyu Liu, and Weidong Zheng
    China Invention Patent Provisional Application , CN114441780A, 2022
  4. A system and method for single cell isolation using droplet microfluidics
    Zida Li, Tao Wang, Yongjin Zhou, and Zengtong Chen
    China Invention Patent Provisional Application , CN113477282A, 2021
  5. A device and method for the assessement of blood viscosity using microfluidics
    Zida Li, Linzhe Chen, Weidong Zheng, Jieying Shan, Yihan Xie, and Xinyu Liu
    China Invention Patent Application , ZL202110639057.6, 2021
  6. The Multiplex Nucleic Acid Quantification Method, Device, and Medium Based on Precipitation Bright Field Image Processing
    Zida Li, Meichi Jin, Jingyi Ding, Yi Wang, and Yu Zhou
    China Invention Patent Application , ZL202310028332.X, 2022
  7. An image-activated picoinjection method, system, and equipment
    Zida Li，Zhantao Zhao
    China Invention Patent Application , ZL202211449260.8, 2023
  8. Method, device, and medium for multiple digital detection of nucleic acid with deep learning
    Zida Li, Qi Fang, and Kai Wu
    China Invention Patent Application , ZL202211516857.X, 2023
  9. Simulation system and method of in vitro diagnostics
    Zida Li, Xiaxia Yu, Xinyu Liu, Jieying Shan, and Yihan Xie
    China Invention Patent Application ,ZL202110750662.0，2023
  10. A fabrication method and application of soft post rings for clot retraction testing
    Zida Li, Lanzhu Huang, and Weidong Zheng
    China Invention Patent Application , ZL202010260648.8, 2022
  11. A microscale device for blood coagulation assay
    Jianping Fu, Kevin Ward, Zida Li, and Xiang Li
    U.S. Patent Application , 62/304,385, 2018
  12. System and method for generation of emulsions with low interfacial tension and measuring frequency vibrations in the system
    Ho Cheung Shum, Alban Sauret, Zida Li, and Yang Song
    U.S. Patent Application , 13/839,072, 2013